Abstract: Objective　To explore the expression of monokine induced by interferon- γ (Mig) in serum and chemokine receptor 3(CXCR3)on lymphocytes of peripheral blood in children with bronchiolitis. Methods　In this study, 55 patients with bronchiolitis in our hospital were randomly recuited, and were divided into two groups: atopic group and non-atopic group. Of the same age 26 healthy children had been enrolled randomly as control group. The level of CXCR3 expression (CD183) on lymphocytes of peripheral blood was detected by flow cytometry in all children. The level of Mig in serum was assayed by ELISA. Results　The level of CD183 expression on the CD3+CD4+T lymphocytes in atopic group and non-atopic group(16.39±4.13%,14.39±3.74 %)were higher than that of control group (11.17±3.13%, P<0.05)，CD183+CD4+/CD4+% in atopic group were higher than that in non-atopic group(P<0.05). The level of CD183 expression on CD3+CD8+T lymphocytes in atopic group and non-atopic group(67.18±10.57 %, 61.44±11.46 %)were higher than that of control group (51.19±5.42 %, P<0.05), CD183+CD8+/CD8+% in atopic group were significantly higher than that in non-atopic group(P<0.05). The level of Mig in serum of children with bronchiolitis in atopic group and non-atopic group(99.67±35.77ng/L, 120.28±32.28ng/L)were significantly higher than that in control group(63.90±15.82 ng/L, P<0.05). The level of Mig in non-atopic group was higher than that in atopic group, there was significant difference(P<0.05). Conclusions　Mig and CXCR3 are involved in the pathogenesis of bronchiolitis, and CXCR3 may relate to allergic factors.